From the Department of Physiology Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract: (3932 Views)
The present work was performed to show the possible interaction of GAB A, and
GABAB receptors in catalepsy. The following results were obtained:
1- Muscimol (MUS), a GABAA agonist, induced catalepsy. This effect was
dose-dependent. Baclofen (BAC), a GABAB agonist, had no effect in this respect.
2- Catalepsy induced by muscimol was potentiated by pretreatment of animals
with bicuculline (BIC), a GABAA antagonist, while pretreatment of animals with
picrotoxin (PIC), another GABAA antagonist, did not change the response.
3- The cataleptogenic effect of a-flupenthixol (a-FPT), a neuroleptic which is a
potent cataleptogenic drug, was also increased by bicuculline pretreatment. Aflupenthixol,
in animals pretreated with picrotoxin, induced a small but significant
increase in catalepsy.
4- Muscimol catalepsy may be due to GABA inhibitory effect of the drug upon
dopaminergic function, while potentiation of cataleptogenic effect of a-flupenthixol
or that of muscimol by bicuculline may be exerted through release of GABA from
GABAergic nerve endings