Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Thu, Dec 5, 2024
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Volume 6, Issue 4 (2-1993)
Med J Islam Repub Iran 1993 |
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ZARRINDAST M, KHAlENABI Y, POURGHOLAMI M H. BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATION. Med J Islam Repub Iran 1993; 6 (4) :285-289
URL: http://mjiri.iums.ac.ir/article-1-1474-en.html
URL: http://mjiri.iums.ac.ir/article-1-1474-en.html
From the Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract: (4180 Views)
Intraperitoneal (IP) injection of bupropion (3,6,
amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing
response induced by both drugs were decreased in animals pretreated either with
the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor
blocker phenoxybenzamine decreased the climbing induced by both bupropion
and amphetamine, but the β-adrenergic blocker propranolol and the antimuscarinic
agent atropine had no effect. Reserpine pretreatment abolished the climbing
induced by bupropion but not that of amphetamine. However, alpha-methyl-ptyrosine
combined with reserpine treatment reduced the amphetamine-induced
climbing. It is concluded that both bupropion and amphetamine-induced climbing
through release of dopamine and subsequent activation of 0-1/0-2 receptors
however, the mechanisms by which dopamine is released by these drugs may
differ.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Pharmacology
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