MOSHTAGHIE A, ANI M. THE EFFECT OF ALUMINUM ON BIOCHEMICAL PARAMETERS RELATED TO BONE METABOLISM. A MODEL STUDY OF HEMODIALYSIS PATIENTS. Med J Islam Repub Iran 1992; 6 (2) :143-145
URL:
http://mjiri.iums.ac.ir/article-1-1496-en.html
From the Dept. of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Abstract: (4314 Views)
The influence of aluminum on some serum parameters related to bone
metabolism has been investigated by daily administration of aluminum over
different periods of time. Daily administration of aluminum (1 mg/kg BW)
for 20 or 50 days elevated serum phosphorous concentration by 16 percent
and had no significant effect on serum calcium level. When aluminum was
injected as a complex with citric acid (1 :1) there was a 22 percent elevation in
serum phosphorous concentration, but again had no significant effect on
serum calcium. Same amounts of aluminum caused a 28 percent elevation in
serum alkaline phosphatase (ALKP), but had no significant effect on serum
parathormone (PTH) either with or without citric acid. A marked reduction
(about 41 percent) in serum calcitonin was observed when rats were given
aluminum with or without citric acid. The relationship between aluminum
toxicity and osteomalacia has been discussed.