Volume 6, Issue 1 (5-1992)                   Med J Islam Repub Iran 1992 | Back to browse issues page

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AL-SHARIFI M. N-GLUCOSIDES: NEW PHASE-II METABOLITES OF TWO BARBITURATES. Med J Islam Repub Iran 1992; 6 (1) :63-66
URL: http://mjiri.iums.ac.ir/article-1-1511-en.html
N-GLUCOSIDES: NEW PHASE-II METABOLITES OF TWO BARBITURATES
MA AL-SHARIFI
From the Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Abstract:   (3756 Views)
The new phase-II N-glucoside metabolites of butobarbitone and pentobarbitone are identified and quantified in human urine after single doses of these drugs. The identification and quantification of these metabolites were carried out by mass spectroscopy technique (accurate mass measurement and high voltage scanning). It was found that the butobarbitone N-glucoside comprised 26% of the dose with tl/2= 44h, while the pentobarbitone N-glucoside was 43% with t1/2= 40h.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Pharmacology
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