Volume 3, Issue 3 And 4 (11-1989)                   Med J Islam Repub Iran 1989 | Back to browse issues page

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AFSHARYPOUR S, HAERY A. EFFECT OF GLUCOSINOLATE AUTOLYSIS PRODUCTS ON RAT SERUMT3 AND T4 CONCENTRATIONS . Med J Islam Repub Iran 1989; 3 (3 and 4) :165-168
URL: http://mjiri.iums.ac.ir/article-1-1584-en.html
EFFECT OF GLUCOSINOLATE AUTOLYSIS PRODUCTS ON RAT SERUMT3 AND T4 CONCENTRATIONS
SULEIMAN AFSHARYPOUR , ALI HAERY
From the Faculty of Pharmacy, and the School of Medicine, Department of Pharmacology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Abstract:   (3876 Views)
The glucosinolate autolysis products of crushed seeds of DesclIrainia sophia L. (khakeshi) and Brassica napus L. (shelghem) were administered orally to rats in doses representing 8,16 and 32 gm seeds/kg body weight/day at intervals of 10, 20 and sometimes 30 days. Serum T3 and T4 concentrations were reduced in 10 day•autolysate treated animals in a similar fashion to that found with methimazole. The antithyroid effect persisted until day 20, but was weaker than that seen with methimazole. By day 30, serum T3 and T4 concentrations returned to normal in plant treated animals.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Pharmacology
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