Volume 19, Issue 2 (8-2005)                   Med J Islam Repub Iran 2005 | Back to browse issues page

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MOOSAVI A S, TEHRANIAN A, BEHTASH N, MODARES GILANI M, GHAEM-MAGHAMI F. LONG TERM ORAL ETOPOSIDE AS SECOND-LINE THERAPY IN RECURRENT EPITHELIAL CARCINOMA OF THE OVARY. Med J Islam Repub Iran 2005; 19 (2) :159-164
URL: http://mjiri.iums.ac.ir/article-1-1602-en.html
LONG TERM ORAL ETOPOSIDE AS SECOND-LINE THERAPY IN RECURRENT EPITHELIAL CARCINOMA OF THE OVARY
AZAM SADAT MOOSAVI , AFSANEH TEHRANIAN , NADEREH BEHTASH , MITRA MODARES GILANI , FATEMEH GHAEM-MAGHAMI
From the department of Gynecology /oncology, Vali Asr Hospital, Vali Asr reproductive Research center, Tehran University of Medical Sciences, Tehran, Iran. , a3064@sina.tums.ac.ir
Abstract:   (4677 Views)
Background: The activity and toxicity of etoposide in women with recurrent ovarian cancer was evaluated in a case series of women with recurrent ovarian cancer who had measurable disease, Methods: All patients had plior platinum-based chemotherapy and developed progressive disease, Etoposide was given as 50mg/day for 21 days every 4 weeks until progression of disease or prohibitive toxicity, Between December 1999 and January 2004,32 patients were enrolled in this study. Results: 30 patients received a total of 133 cycles of etoposide. Median age was 49 years (range, 19 to 75). The median number of etoposide cycles was 4 (range, 1 to 12). There were 5 partial responses (16.6%). The mean response duration was 4.8 months (range, 3.5 to 6). median progression-free interval CPFI) was 7 months (range, 3 to 13), and median survival time was 12.5 months (range. 1.3 to 36). Conclusion: The major toxicity was leukopenia. One patient required red blood cell transfusions, and the main non-hematologic toxicity was nausea and vomiting. There were no treatment-related mortalities. Although etoposide appears to exhibit modest activity in recurrent ovarian cancer after platinum-based therapy, response and survival durations are short.
Keywords: Oral etoposide, recurrent epithelial ovarian cancer, second-line chemotherapy
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Type of Study: Original Research: Basic Science in Medicine | Subject: Oncology
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