Volume 5, Issue 3 And , 4 (11-1991)                   Med J Islam Repub Iran 1991 | Back to browse issues page

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GHAFGHAZI T, JAMSHIDI H, GHORBANI A. ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS. Med J Islam Repub Iran 1991; 5 (3) :135-137
URL: http://mjiri.iums.ac.ir/article-1-1626-en.html
ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS
T GHAFGHAZI , H.R JAMSHIDI , A GHORBANI
From the Departments of Pharmacology and Neurology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Abstract:   (3676 Views)
35 epileptic patients, aged 10 to 58 years (mean 23), who were taking anticonvulsant drugs were studied. The patients exhibited a 34% reduction in serum calcium levels, a 41 % increase in serum alkaline phosphatase activity and a slight but insignificant decrease in serum phosphate, compared to untreated controls. These changes appear to be related to the anticonvulsant drug taken, in the following order of decreasing importance: phenytoin + phenobarbital + carbamazepine phenytoin + phenobarbital phenytoin + carbamazepine,and phenobarbital + carbamazepine. It is possible that anticonvulsant drugs alter vitamin D metabolism which results in disturbance of calcium homeostasis. Moreover these changes in serum calcium and alkaline phosphatase activity in anticonvulsant treatment patients are similar to those in patients with osteomalacia.
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Type of Study: Original Research | Subject: Pharmacology
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