Volume 9, Issue 4 (2-1996)                   Med J Islam Repub Iran 1996 | Back to browse issues page

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KUCHARZ E. INFLUENCE OF GLYCOSAMINOGLYCANS ISOLATED FROM THE RAT LIVER WITH VARIOUS STAGES OF CARBON TETRACHLORIDE-INDUCED FIBROSIS UPON COLLAGEN FIBRILLOGENESIS IN VITRO. Med J Islam Repub Iran 1996; 9 (4) :327-332
URL: http://mjiri.iums.ac.ir/article-1-1651-en.html
INFLUENCE OF GLYCOSAMINOGLYCANS ISOLATED FROM THE RAT LIVER WITH VARIOUS STAGES OF CARBON TETRACHLORIDE-INDUCED FIBROSIS UPON COLLAGEN FIBRILLOGENESIS IN VITRO
E.J KUCHARZ
From the Department of Internal Medicine, Silesian University School of Medicine, Tychy, Poland.
Abstract:   (4069 Views)
The influence of glycosaminoglycans (GAG) on collagen fibrillogenesis in vitro was investigated. GAG and collagen were isolated from the liver of rats treated with carbon tetrachloride at various time intervals (3-16 weeks). It was found that GAG obtained from the fibrotic liver accelerated collagen fibril formation. This effect was more evident in a solution of type I collagen than type III collagen. Studies on the liver samples showed that collagen was relatively slowly liberated in a solution of acid from the fibrotic liver as compared to normal tissue. The observed phenomena were related to the stage of fibrosis, i.e., to the duration of carbon tetrachloride treatment. Therefore, a role for GAG alteration in the development of hepatic fibrosis is suggested.
Keywords: Hepatic fibrosis, collagen, fibrillogenesis, glycosaminoglycan.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Internal Medicine
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