Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Wed, Dec 4, 2024
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Volume 14, Issue 3 (11-2000)
Med J Islam Repub Iran 2000 |
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ZARRINDAST M, REZAYAT M, ZOLFAGHARPOOR M. EFFECTS OF CCK RECEPTOR AGONISTS AND ANTAGONISTS ON MORPHINE-INDUCED ANTINOCICEPTION IN MICE. Med J Islam Repub Iran 2000; 14 (3) :261-266
URL: http://mjiri.iums.ac.ir/article-1-1652-en.html
URL: http://mjiri.iums.ac.ir/article-1-1652-en.html
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Abstract: (3699 Views)
In the present study the effects of both CCK receptor agonists and antagonists
on antinociception induced by morphine in the tail-flick test have been evaluated.
M orphine induced dose-dependent antinociception in mice. The response of
morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by
unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329
and L-365, 260 decreased the potentiation of morphine antinociception induced
by CCK-8S.•The antagonists even decreased the response induced by morphine
in the pre5ence ofCCK-8U. High doses ofMK-329 and L-365, 260 also potentiated
morphine's antinociception. Single administration of the CCK receptor agonists
CCK-8 and CCK-8U or CCK receptor antagonists did not elicit any response
in the tail-flick test. It is concluded that CCK receptor mechanisms are
involved in the modulation of pain response and/or morphine antinociception.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Pharmacology
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