Medical Journal of The Islamic Republic of Iran (MJIRI)

  Absract

  Intracranial invasion of cellular blue nevus (CBN) from the skin is extremely rare

  and such a condition with malignant transformation is even rarer. A case of

  meningeal melanoma with malignant transformation which was derived from an Ota

  nevus is presented in this report.

  A21-year-old man with a neurocutaneous syndrome since childhood was referred

  with headache and mild left hemiparesia. CT scan and MRI demonstrated intracranial

  lesions and conjunctival biopsy leads to the pathologic diagnosis of blue nevus.

  Thereafter his parietal lesion was operated by craniotomy with total gross excision.

  On histopathological examination, diagnosis of malignant melanoma was confirmed.

  Approximately 2 months after radiotherapy and chemotherapy, he afflicted to

  diplopia and blurred vision on the leftside due to enlargement of orbital and cavernous

  sinus lesion. Following one year follow-up, he was survived and thrived with

  diffuse leptomeningeal nodular enhancement in favor of melanoma dissemination.

  Primary intracranial melanomas are though rare, but it should be suspected especially

  in the presence of periorbital blue nevus or nevus of Ota. Moreover, although CBN

  is considered benign, scalp or periorbital CBN has the potential for intracranial invasion and malignant transformation.