Volume 28, Issue 1 (1-2014)                   Med J Islam Repub Iran 2014 | Back to browse issues page

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Shidfar F, Zarrati M, Khamseh M E, Haghighat N, Rostami A, Zolfaghari H. Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes. Med J Islam Repub Iran 2014; 28 (1) :646-652
URL: http://mjiri.iums.ac.ir/article-1-2455-en.html
Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes
Farzad Shidfar , Mitra Zarrati , Mohamad Ebrahim Khamseh , Neda Haghighat , Ali Rostami , Hamid Zolfaghari
Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. , h.z.7025@gmail.com
Abstract:   (4442 Views)

  Background :Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM).

  Methods : From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method. Apo-B100 and apo-A1 were measured by immunoturbidimetry with a Cobas MIRA analyzer. HOMA-IR was calculated by the following formula: [fasting insulin (uIU/mL) × fasting blood glucose (mmol/L)]/22.5.

  Results : The mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (pfor trend=0.04) in women but not men. Fetuin-A had just a significant positive correlation withApo- A1(r=0.22, p=0.02).

  Conclusion : This present study showed that levels of serum fetuin-A are significantly associated with insulin resistance in women with T2DM.

Keywords: Fetuin-A, Apo-A1, Apo-B100, Body Fat Percentage, Insulin Resistance, Type 2 Diabetes.
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Type of Study: Original Research | Subject: Endocrinology
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