Volume 28, Issue 1 (1-2014)                   Med J Islam Repub Iran 2014 | Back to browse issues page

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Almassinokiani F, Almasi A, Akbari P, Saberifard M. Effect of Letrozole on endometriosis-related pelvic pain. Med J Islam Repub Iran 2014; 28 (1) :695-701
URL: http://mjiri.iums.ac.ir/article-1-2479-en.html
Iran University of Medical Sciences, Firoozgar Hospital, Tehran, Iran. , a_almasi_n@hotmail.com
Abstract:   (3549 Views)

  Background : To determine the role of Letrozole, an aromatase inhibitor,in the treatment of endometriotic pain.

  Methods: In this prospective, randomized, controlled clinical trial in minimallyinvasive surgery research center,51 women with pelvic endometriosis and endometriotic pain (dyspareunia, dysmenorrhea, pelvic pain) score of 5 or more (for at least one of these endometriotic pain), after laparoscopic diagnosis and conservative laparoscopic surgery were treated with either Letrozole plus OCP (n=25) or only OCP (n=26) for 4 months continuously.

  Results: Using VAS test, the score of dyspareunia, dysmenorrhea and pelvic pain 4 months after the laparoscopic surgery declined significantly in both groups but the difference between results of the two groups was not significant.

  Conclusion: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis and in comparison with OCP, Letrozole did not affect the outcome.

 

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Type of Study: Original Research | Subject: Gynecology & Obstetrics

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