Volume 29, Issue 1 (1-2015)                   Med J Islam Repub Iran 2015 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Nikbakht Dastjerdi M, Momeni M, Bidaki R, Khaleghinia M, Karimi-Googheri M, Kazemi Arababadi M et al . The effect of depression and anxiety on expression levels of toll like receptor signaling moleculesin chronic HBV infected patients. Med J Islam Repub Iran 2015; 29 (1) :169-173
URL: http://mjiri.iums.ac.ir/article-1-2698-en.html
The effect of depression and anxiety on expression levels of toll like receptor signaling moleculesin chronic HBV infected patients
Mehdi Nikbakht Dastjerdi , Mohammad Momeni , Reza Bidaki , Mehdi Khaleghinia , Masoud Karimi-Googheri , Mohammad Kazemi Arababadi , Ahmad Shabanizadeh
Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , shebani54@yahoo.com
Abstract:   (5454 Views)

  Background: Toll- like receptors (TLRs) play an important role in the recognition of DAMPs and PAMPs and induction ofinflammation. Previous studies demonstrated that depression and anxiety can influence the expression levels of immune related molecules. Our previous study revealed that mRNA levels of IRAK4, TRAF3 and IRF7 were significantly decreased in chronic HBV infected (CHB) patients when compared to healthy controls. Therefore, the aim of this study was to evaluate the effects of depression and anxiety on the expression levels of these molecules in CHB patients.

  Methods : Sixty CHB patients participated in this studyand filled out the standard questionnaires and the expression of IRAK4, TRAF3 and IRF7 were examined using Real-Time PCR techniques.

  Results : The results of this study demonstrated that expression of IRAK4, TRAF3 and IRF7 did not differ between patients with various stages of depression and anxiety (all p>0.05).

  Conclusion : According to the results, it seems that declined expression of IRAK4, TRAF3 and IRF7 inCHB patients were not related to depression and anxiety, and other factors including genetic and immunoregulatory effects of HBV may be responsible for the declined expression of these molecules.

Keywords: Depression, Anxiety, Chronic HBV infection, IRAK4, TRAF3, IRF7.
Full-Text [PDF 461 kb]   (1415 Downloads)    
Type of Study: Original Research | Subject: Anatomical Sciences
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.