Volume 29, Issue 1 (1-2015)                   Med J Islam Repub Iran 2015 | Back to browse issues page

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Mohammadi Z, Keshtkar A, Fayyazbakhsh F, Ebrahimi M, Amoli M M, Ghorbani M, et al . Prevalence of osteoporosis and vitamin D receptor gene polymor-phisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS). Med J Islam Repub Iran 2015; 29 (1) :615-621
URL: http://mjiri.iums.ac.ir/article-1-3024-en.html
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. , mahsaamoli@hotmail.com
Abstract:   (4980 Views)

  Background: Osteoporosis, or porous bone, is a disease characterized by low bone mass density (BMD) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. There are numerous risk factors for osteoporosis. While many of these factors are non-genetic in nature, there is a definite genetic component responsible for this condition. The main aim of this study was to evaluate the association between VDR (Vitamin D receptor gene) polymorphisms (Fok1) A>G (rs2228570) and bone mineral density in an Iranian defined population.

  Methods : The study participants comprised of 1032 Iranians recruited from the city of Sanandaj during IMOS (Iranian Multi Center Osteoporosis Study). Bone mineral density measurement was performed in all the participants with and without osteoporosis. All samples were genotyped for VDR genes (Fok1) polymorphism with polymerase chain reaction, using a predesigned TaqMan allele discrimination assay.

  Results : There was a significant association between Fok1 polymorphism and osteoporosis in post-menopausal women, 0.138(0.025-0.768).

  Conclusion : It seems that cohort studies, which are more powerful than case-control studies, can be useful in evaluating the roles of genetic variants as risk or protective factors for osteoporosis.

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Type of Study: Original Research | Subject: Human Genetics

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