Medical Journal of The Islamic Republic of Iran (MJIRI)

Background: Restricted intakes of saturated and trans-fatty acids and replacement with poly or monounsaturated fatty acids are
emphasized in healthy diets. This study evaluates the effects of a six-month consumption of canola oil compared to sunflower oil on
lipid profile and anthropometric parameters of people affected by dyslipidemia.
Methods: This randomized controlled trial was conducted on 96 patients with dyslipidemia, who were randomly assigned into canola
oil or the sunflower oil groups. The participants were instructed to record the contents of their daily meals, beverages, fruits, and
snacks a day before treatment, at the second clinic visit, in the third month, and at the end of study (i.e., six months). Lipid profile and
anthropometric parameters were compared between the two groups. Student t-test or Mann Whitney U test was used for statistical
comparisons of variables between groups. Multivariate analysis was performed to adjust the confounding factor effects.
Results: Of the enrolled participants, 44 (45.8%) were on sunflower oil diet and 52 (54.2%) on canola oil diet. We observed no
change in anthropometric parameters and thus no significant difference between the two groups (p>0.05). Significant reductions in
LDL-C (p<0.001), total cholesterol (p<0.001) and triglyceride levels (p<0.001), and significant elevation in HDL-C (p=0.008) were
observed in canola oil group, as well as those who used sunflower oil.
Conclusion: Dietary fats in the form of canola oil or sunflower oil effectively lower the serum cholesterol, LDL-C and triglyceride
concentrations. They also result in an increase in serum concentration of HDL-C. These oils, however, did not modify general anthropometric
parameters.