Volume 32, Issue 1 (2-2018)                   Med J Islam Repub Iran 2018 | Back to browse issues page

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Zarrin R, Bagheri M, Mehdizadeh A, Ayremlou P, Faghfouri A H. The association of FokI and ApaI polymorphisms in vitamin D receptor gene with autoimmune thyroid diseases in the northwest of Iran . Med J Islam Repub Iran 2018; 32 (1) :18-21
URL: http://mjiri.iums.ac.ir/article-1-4739-en.html
The association of FokI and ApaI polymorphisms in vitamin D receptor gene with autoimmune thyroid diseases in the northwest of Iran
Rasoul Zarrin , Morteza Bagheri , Alireza Mehdizadeh , Parvin Ayremlou , Amir Hossein Faghfouri
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. , amir.nut89@gmail.com
Abstract:   (3863 Views)
Background: Some genetic factors are involved in the etiology of Hashimoto thyroiditis and Graves’ disease as autoimmune thyroid diseases (AITDs). Effects of vitamin D receptor gene polymorphisms in AITDs development have already been investigated in some previous studies. However, no study has been done on the association between VDR FokI and ApaI polymorphisms and AITDs in an Iranian population. In this study, the possible effects of FokI and ApaI polymorphisms on AITDs were investigated in the population of northwest of Iran.
   Methods: A total of 121 AITDs adult patients and 117 healthy controls matched by age and sex in the same population were included in this study. FokI and ApaI polymorphisms were genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). Chi-square test and odds ratio (OR) with 95% CI were used to analyze the data.
   Results: FokI and ApaI genotypes frequencies were not significantly different between the 2 groups (p= 0.06, p= 0.73, respectively). However, FokI "CC" and "CT" genotypes were related to AITDs risk (p= 0.03; OR= 3.75; 95% CI, 1.16-12.17 and p= 0.04; OR= 3.41; 95% CI, 1.03-11.28, respectively).
   Conclusion: These data suggest that FokI polymorphisms are involved in AITDs susceptibility in the population of northwest of Iran.
 
 
Keywords: Vitamin D receptor, Genetic polymorphisms, Hashimoto disease, Graves’ disease
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Type of Study: Original Research | Subject: Cellular & Molecular Research
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