Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Fri, Nov 29, 2024
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Volume 32, Issue 1 (2-2018)
Med J Islam Repub Iran 2018 |
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Kiani S J, Javanmard D, Ghaffari H, Tavakoli A, Mortazavi H S, Bokharaei-Salim F, et al . Molecular prevalence of parvovirus B19 among HIV1-infected patients in Iran
. Med J Islam Repub Iran 2018; 32 (1) :659-662
URL: http://mjiri.iums.ac.ir/article-1-5122-en.html
URL: http://mjiri.iums.ac.ir/article-1-5122-en.html
Seyed Jalal Kiani 
, Davod Javanmard , Hadi Ghaffari , Ahmad Tavakoli , Helya Sadat Mortazavi , Farah Bokharaei-Salim , Zahra Bangaleh , Seyed Hamidreza Monavari
, Davod Javanmard , Hadi Ghaffari , Ahmad Tavakoli , Helya Sadat Mortazavi , Farah Bokharaei-Salim , Zahra Bangaleh , Seyed Hamidreza Monavari
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran , monavari.hr@iums.ac.ir
Abstract: (6708 Views)
Background: Different outcomes of parvovirus B19 (B19V) infection in immunocompromised patients, including HIV1-infected persons, may be life-threatening. Considering the hematologic disorders associated with B19V infection, this study aimed to investigate the prevalence of B19V infection among HIV1-infected individuals in Iran.
Methods: Serum samples from 100 HIV1-infected patients were analyzed for B19 viral DNA using real-time PCR assay. COBAS TaqMan HIV-1 test was performed for quantitative measurements of HIV-1 RNA in the patients’ sera.
Results: Real-time PCR analysis revealed that 10 out of 100 cases (10%) were positive for B19V infection. Across various age groups, the B19V infection was more prevalent among patients within the age range of 21-40 years. Higher prevalence of B19V infection was observed among HIV1-infected patients with a viral load of higher than 400 copies/mL.
Conclusion: Despite limitations, this study may set the stage for further evaluations with larger sample sizes to elucidate the potential role of B19V in hematologic disorders, which may result in exacerbation of the disease in HIV1-infected patients. Moreover, as it has been shown that B19V infection can be treated using intravenous immunoglobulin (IVIG) therapy, available treatments may help improve the quality of life in HIV-infected persons.
Methods: Serum samples from 100 HIV1-infected patients were analyzed for B19 viral DNA using real-time PCR assay. COBAS TaqMan HIV-1 test was performed for quantitative measurements of HIV-1 RNA in the patients’ sera.
Results: Real-time PCR analysis revealed that 10 out of 100 cases (10%) were positive for B19V infection. Across various age groups, the B19V infection was more prevalent among patients within the age range of 21-40 years. Higher prevalence of B19V infection was observed among HIV1-infected patients with a viral load of higher than 400 copies/mL.
Conclusion: Despite limitations, this study may set the stage for further evaluations with larger sample sizes to elucidate the potential role of B19V in hematologic disorders, which may result in exacerbation of the disease in HIV1-infected patients. Moreover, as it has been shown that B19V infection can be treated using intravenous immunoglobulin (IVIG) therapy, available treatments may help improve the quality of life in HIV-infected persons.
Type of Study: Original Research |
Subject:
Virology
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