Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Tue, Nov 26, 2024
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Volume 32, Issue 1 (2-2018)
Med J Islam Repub Iran 2018 |
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Yousefi Ghalejoogh Z, Mirakhor Samani S, Shatizadeh Malekshahi S, Shahsiah R, Yavarian J, Kiani S J. Human papilloma virus infection and fascin over-expression in squamous cell carcinoma of the cervix
. Med J Islam Repub Iran 2018; 32 (1) :784-788
URL: http://mjiri.iums.ac.ir/article-1-5284-en.html
URL: http://mjiri.iums.ac.ir/article-1-5284-en.html
Zohreh Yousefi Ghalejoogh 
, Simin Mirakhor Samani , Somayeh Shatizadeh Malekshahi , Reza Shahsiah , Jila Yavarian , Seyed Jalal Kiani
, Simin Mirakhor Samani , Somayeh Shatizadeh Malekshahi , Reza Shahsiah , Jila Yavarian , Seyed Jalal Kiani
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , kiani.j@iums.ac.ir
Abstract: (4107 Views)
Background: Human papilloma virus (HPV) is involved in development of almost all cervical cancers, mainly through the subversion of cellular mechanisms of growth control. Fascin plays central role in subsequent cell transformation events. Fascin mediates stabilization of parallel actin bundles where cellular protrusions are formed; this represents primary stages of cell migration and metastasis. Immunohistochemical assays have shown up-regulation of fascin expression in many epithelial and non-epithelial neoplasms. Therefore, the aim of this study was to investigate HPV infection and fascin expression in samples of cervical cancer.
Methods: Of 66 patients with confirmed SCC, formalin-fixed specimens, embedded in paraffin blocks were evaluated for HPV infection with nested multiplex polymerase chain reaction (NM-PCR) and for fascin expression with immunohistochemical assays. Statistical analysis was performed using Wilcoxon rank-sum test and SPSS software. A p<0.05 was considered for statistical significance.
Results: Of 66 samples, 52 (78.7%) were found positive for HPV infection and fascin over-expression was shown in all squamous cell carcinoma samples.
Conclusion: This study showed fascin overexpression in squamous cell carcinoma of the cervix which might be involved in metastasis of cancers induced by some types of HPV, hypothetically through attenuation of inter-cellular adhesions, and induction of cell motility.
Methods: Of 66 patients with confirmed SCC, formalin-fixed specimens, embedded in paraffin blocks were evaluated for HPV infection with nested multiplex polymerase chain reaction (NM-PCR) and for fascin expression with immunohistochemical assays. Statistical analysis was performed using Wilcoxon rank-sum test and SPSS software. A p<0.05 was considered for statistical significance.
Results: Of 66 samples, 52 (78.7%) were found positive for HPV infection and fascin over-expression was shown in all squamous cell carcinoma samples.
Conclusion: This study showed fascin overexpression in squamous cell carcinoma of the cervix which might be involved in metastasis of cancers induced by some types of HPV, hypothetically through attenuation of inter-cellular adhesions, and induction of cell motility.
Type of Study: Original Research |
Subject:
Oncology
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