Volume 34, Issue 1 (2-2020)                   Med J Islam Repub Iran 2020 | Back to browse issues page

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Momeni-Varposhti Z, Kazemi M H, Talebi M, Chegeni R, Roshandel E, Hajifathali A et al . Plasma levels of norepinephrine and expression levels of ß2-adrenergic receptor gene correlate with the incidence of acute graft-versus-host disease. Med J Islam Repub Iran 2020; 34 (1) :1037-1043
URL: http://mjiri.iums.ac.ir/article-1-6045-en.html
Plasma levels of norepinephrine and expression levels of ß2-adrenergic receptor gene correlate with the incidence of acute graft-versus-host disease
Zahra Momeni-Varposhti , Mohammad Hossein Kazemi , Mehdi Talebi , Rouzbeh Chegeni , Elham Roshandel , Abbas Hajifathali , Ali Akbar Movassaghpour
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , Movassaghpour@gmail.com
Abstract:   (1293 Views)
Background: Acute graft-versus-host disease is a major complication in allogeneic hematopoietic stem-cell transplantation. Epinephrine and norepinephrine are stress hormones which affect many cells, including immune cells through interaction with adrenergic receptors, mainly b2-adrenergic receptor. The immunomodulatory effects of epinephrine, norepinephrine, and signaling of the adrenergic receptor have been shown to decrease the probability of the acute graft-versus-host disease in animal models. The aim of our study was to investigate the possible correlations between the serum levels of epinephrine and norepinephrine and also leukocytic expression levels of b2-adrenergic receptor with the incidence of acute graft-versus-host disease in patients undergoing allogeneic hematopoietic stem-cell transplantation.
   Methods: In this study, the plasma levels of epinephrine and norepinephrine and the leukocytic expression of b2-adrenergic receptor gene were measured and compared in allogeneic hematopoietic stem-cell transplantation patients with and without acute graft-versus-host disease. Data were analyzed and illustrated using SPSS 19 and GraphPad Prism 6. The student T-test, Pearson, and Spearman’s tests were performed and p<0.05 was considered as significant.
   Results: We showed that the plasma levels of norepinephrine and the relative amount of the mRNA of b2-adrenergic receptor at 7 and 21 days after allogeneic hematopoietic stem-cell transplantation were significantly lower in patients with acute graft-versus-host disease than recipients without acute graft-versus-host disease. There were also negative correlations between the plasma levels of norepinephrine, leukocytic levels of the mRNA of b2-adrenergic receptor, and the incidence of acute graft-versus-host disease.
   Conclusion: Our results suggest that stress hormones and their receptor might have a role in preventing acute graft-versus-host disease and could be promising factors in controlling the outcome of allogeneic hematopoietic stem-cell transplantation.
 
Keywords: Norepinephrine, Epinephrine, 2-adrenergic receptor, Acute graft-versus-host disease
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Type of Study: Original Research | Subject: Cellular & Molecular Research
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