TALEBPOOR M, KARBAKHSH M, SABETI S, ZARGAR M. SYNCHRONOUS SURGICAL REMOVAL OF SUSPICIOUS OVARIAN METASTASES FROM COLORECTAL CANCER. Med J Islam Repub Iran 2005; 18 (4) :285-288
URL:
http://mjiri.iums.ac.ir/article-1-607-en.html
From Sina Trauma & Surgery Research Center, Sina Hospital. Tehran University of Medical Sciences.Tehran. I.R. Iran.
Abstract: (4975 Views)
Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical
resection of a primary colorectal cancer. In this study we examined the characteristics
of women with colorectal cancer for whom synchronous oophorectomy had been
performed.
In this cross-sectional study, records of patients with colorectal cancer from April
1991 through October 1999 who had undergone surgery for both colorectal cancer resection
and oophorectomy for suspicious ovarian metastasis in the Cancer Institute, Imam Khomeini
Medical Center, were reviewed. SPSS version 10 was used for statistical analysis.
The studied cases (n= 82) comprised 44.1 percent of all recorded cases of women
with colorectal cancer during this period (N= 186). The mean age of our cases was
52.19 years. 54.9% of the studied women were in stage C of colorectal cancer. The
commonest pathology of tumors was adenocarcinoma (89%). Well differentiated carcinoma
was observed in 43.9%, followed by moderately differentiated carcinoma in
37.8%, poorly differentiated in 12.2% and unspecified in 6.1 %. 22 of our patients
(26.8%) had gross abnormalities of ovaries at operation. In 13 cases (15.8% of our 82
studied cases and 6.99% of all 186 women with colorectal cancer), tumoral involvement
of ovaries was proven through pathologic examination. 10 out of these 13 cases
were among those with gross abnormalities of ovaries at operation (p= 0.048). Among
the 13 patients with ovarian metastasis, 11 cases (84.6%) were in stage C at operation
(p= 0.02) and 7 (53.8%) had well differentiated carcinoma (p= 0.04).
Patients with ovarian metastases of colorectal origin are generally peri- or post menopausal.
Like similar studies, in our setting, about 7 percent of all recorded female
cases with colorectal cancer turned out to have ovarian metastases in surgical pathologic
examination. In fact, 15.8% of our 82 cases sustaining surgery for "colorectal
cancer and suspicious ovarian metastasis" proved to have ovarian metastasis. We recommend
that prophylactic oophorectomy be performed in postmenopausal women
with advanced stage colorectal cancer or any other woman with colorectal cancer with
gross abnormality of the ovaries at operation.