Volume 18, Issue 4 (11-2005)                   Med J Islam Repub Iran 2005 | Back to browse issues page

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MANSOURI TORGHABEH H, POURFATHOLLAH A A, MAHMOODIAN SHOOSHTARI M, REZAIE YAZDI Z, ESMAILI H. FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY. Med J Islam Repub Iran 2005; 18 (4) :309-313
URL: http://mjiri.iums.ac.ir/article-1-612-en.html
FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
HASSAN MANSOURI TORGHABEH , ALI AKBAR POURFATHOLLAH , MAHMOOD MAHMOODIAN SHOOSHTARI , ZAHRA REZAIE YAZDI , HABIBOLLAH ESMAILI
the Departmentof Internal Medicine, Mashhad Medical Sciences University, Mashhad , Rezaieyazdi-z@mums.ac.ir
Abstract:   (4118 Views)
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII inhibitors and two patients had none. Because factor V and factor VIII share approximately 40% amino acid sequence homology in their A and C domains, it remains to be elucidated if it is one molecule that recognizes both factor V and VIII or whether there are two inhibitor molecules against common sites.
Keywords: Combined factor V & VIII deficiency, Factor V inhibitor, Factor VIII inhibitor.
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Type of Study: Original Research: Clinical Science | Subject: Heart
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