Medical Journal of The Islamic Republic of Iran (MJIRI)

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In order to determine outcome of pregnancy with lUI in patients with unexplained recurrent miscarriage whose husbands have low hypo-osmotic swelling test scores, a prospective clinical intervention was performed at a university referral clinic of recurrent abortion. Out of 56 patients whose husbands had abnormal hypo-osmotic swelling tests, 43 patients underwent lUI, from which only 14 patients became pregnant (treatment group) and 13 patients became spontaneously pregnant without lUI as control group. Our main outcome measure was successful pregnancy (continuation of pregnancy after 20 weeks). Among the 14 patients who became pregnant, 3 patients aborted below 20 weeks (21.4%), and 11 patients continued pregnancy after 20 weeks of gestation (78.6%). In the control group among the 13 patients with spontaneous pregnancy, 8 patients aborted below 20 weeks (61.5%) and 5 patients continued pregnancy over 20 weeks (36.4%), success rate ratio was 2.04% and the difference was statistically significant (d= 4.49, p<0.05). Treating the unexplained recurrent aborter whose male partner has a low hypo-osmotic swelling test score with lUI could be effective. This is the first study to present an ideal way for selection of recurrent aborters who benefit from lUI. The probable mechanism for this effect may be selection of the best quality sperms which will be discussed in detail.

Keywords: Recurrent miscarriage, Hypo-osmotic swelling test, lUI.

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