Volume 17, Issue 1 (5-2003)                   Med J Islam Repub Iran 2003 | Back to browse issues page

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A. SAMADI A, ALVANI S, GHAZI-KHONSARI M. PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS. Med J Islam Repub Iran 2003; 17 (1) :67-73
URL: http://mjiri.iums.ac.ir/article-1-724-en.html
PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS
A A. SAMADI , S ALVANI , M GHAZI-KHONSARI
From the Dept of Biochemistry, Pasteur Institute of Iran, Tehran , asamadi@kcom.edu
Abstract:   (5101 Views)
Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We examined the activity of arylesterase and paraoxonase among healthy individuals and in patients with hypercholesterolemia. Equal activity distribution was observed among males and females for both enzymes. Arylesterase activity displayed a normal distribution in the population under study. However, paraoxonase activity demonstrated a three modal activity. Population distribution of A, B and AB polymorphism were 46, 10 and 44 percent respectively. A significant direct correlation between paraoxonase activity and triglyceride levels was observed (p
Keywords: Paraoxonase, Arylesterase, Lipids, Lipoproteins, Arteriosclerosis, Polymorphism.
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Type of Study: Original Research | Subject: Clinical Biochemistry
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