Medical Journal of The Islamic Republic of Iran (MJIRI)
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Volume 35, Issue 1 (1-2021)
Med J Islam Repub Iran 2021 |
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Amanollahi A, Sotoodeh Ghorbani S, Basir Ghafouri H, Afrashteh S, Hashemi Nazari S S. Which criteria were used to describe patients with COVID-19? A systematic review and meta analysis of clinical, laboratory, and
imaging features. Med J Islam Repub Iran 2021; 35 (1) :848-858
URL: http://mjiri.iums.ac.ir/article-1-7479-en.html
URL: http://mjiri.iums.ac.ir/article-1-7479-en.html
Alireza Amanollahi 
, Sahar Sotoodeh Ghorbani , Hamed Basir Ghafouri , Sima Afrashteh , Seyed Saeed Hashemi Nazari
, Sahar Sotoodeh Ghorbani , Hamed Basir Ghafouri , Sima Afrashteh , Seyed Saeed Hashemi Nazari
Prevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran , saeedh_1999@yahoo.com
Abstract: (1636 Views)
Background: The unknowingness of COVID-19 compared to other respiratory diseases and gaining an overview of its diagnostic criteria led to this study, which was designed to summarize the signs and symptoms along with the clinical tests that described these patients.
Methods: PubMedMEDLINE, Web of Science, Core Collection, Scopus, and Google Scholar were systematically searched on September 27, 2020. After screening, we selected 56 articles based on clinical characteristics and laboratory and imaging findings in confirmed COVID-19 patients as eligibility criteria. To evaluate risk of bias, the Newcastle Ottawa scale, for publication bias, Egger’s test, and for heterogeneity, I2 and tau test were used; and finally, random-effects models were used for pooled estimation.
Results: Pooled estimates for frequently clinical symptoms were as follows: fever (78% [95% CI, 74-82]), cough (60% [95% CI, 57-63]), and fatigue (31% [95% CI, 26-36]); and they were as follows for laboratory findings in lymphocyte (1.02 [95% CI, 0.92-1.12]), CRP (19.64 [95% CI, 13.96- 25.32]), and platelet count (175.2 [95% CI, 165.2-185.2]); they were as follows for imaging findings in bilateral pneumonia (64% [95% CI, 56-72]), and ground glass opacity (60% [95% CI, 48-7]). Also, in the subgroup analysis, bilateral pneumonia with 18% and fatigue with 15%, had the highest difference in values between the groups.
Conclusion: According to Forest plots, the CI and dispersion among studies were smaller in laboratory findings than in symptom and imaging findings, which might indicate a high alignment in the laboratory findings among studies.
Methods: PubMedMEDLINE, Web of Science, Core Collection, Scopus, and Google Scholar were systematically searched on September 27, 2020. After screening, we selected 56 articles based on clinical characteristics and laboratory and imaging findings in confirmed COVID-19 patients as eligibility criteria. To evaluate risk of bias, the Newcastle Ottawa scale, for publication bias, Egger’s test, and for heterogeneity, I2 and tau test were used; and finally, random-effects models were used for pooled estimation.
Results: Pooled estimates for frequently clinical symptoms were as follows: fever (78% [95% CI, 74-82]), cough (60% [95% CI, 57-63]), and fatigue (31% [95% CI, 26-36]); and they were as follows for laboratory findings in lymphocyte (1.02 [95% CI, 0.92-1.12]), CRP (19.64 [95% CI, 13.96- 25.32]), and platelet count (175.2 [95% CI, 165.2-185.2]); they were as follows for imaging findings in bilateral pneumonia (64% [95% CI, 56-72]), and ground glass opacity (60% [95% CI, 48-7]). Also, in the subgroup analysis, bilateral pneumonia with 18% and fatigue with 15%, had the highest difference in values between the groups.
Conclusion: According to Forest plots, the CI and dispersion among studies were smaller in laboratory findings than in symptom and imaging findings, which might indicate a high alignment in the laboratory findings among studies.
Type of Study: Systematic Review |
Subject:
COVID 19
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