Volume 15, Issue 4 (2-2002)                   Med J Islam Repub Iran 2002 | Back to browse issues page

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SOLEIMAN-NEJAD E, FATHOLLAHI Y, SEMNANIAN S. FORMALIN AS A PERIPHERAL NOXIOUS STIMULUS CAUSES A BIPHASIC RESPONSE IN NUCLEUS PARAGIGANTOCELLULARIS NEURONS. Med J Islam Repub Iran 2002; 15 (4) :231-236
URL: http://mjiri.iums.ac.ir/article-1-788-en.html
FORMALIN AS A PERIPHERAL NOXIOUS STIMULUS CAUSES A BIPHASIC RESPONSE IN NUCLEUS PARAGIGANTOCELLULARIS NEURONS
E SOLEIMAN-NEJAD , Y FATHOLLAHI , S SEMNANIAN
the Institute of Biochemistry and Biophysics. Tehran University. Po.Box: 13145-1384. Tehran.l.R. Iran.
Abstract:   (3917 Views)
The effects of formalin as a peripheral noxious stimulus on the activity of lateral paragigantocellularis nucleus (LPGi) neurons were examined. Spontaneous activity ofLPGi neurons was recorded after confirmation of their responsiveness to acute pain, and thereafter formalin (50 µL, 2.5%) was injected in the contralateral hindpaw. The response of the LPGi neurons was monitored for 60 min. A biphasic response with a peak lasting 3 to 5 min post-injection, and a second more prolonged tonic excitatory response were obtained which corresponds to the nature and time course of behavioral studies. It is concluded that LPGi neurons may be involved in the processing of nociceptive information related to formalin as a noxious stimulus.
Keywords: Nucleus paragigantocellularis, Formalin test, Multiple unit recording, Rat.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Physiology
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