Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Wed, Nov 11, 2026
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Volume 40, Issue 1 (1-2026)
Med J Islam Repub Iran 2026 |
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Rajaei S, Zarepur E, Hosseini Tashnizi S, Zarepur A. Effect of Coenzyme Q10 on Echocardiographic Parameters in Children with Heart Failure due to Dilated Cardiomyopathy: A Clinical Trial. Med J Islam Repub Iran 2026; 40 (1) :906-910
URL: http://mjiri.iums.ac.ir/article-1-7983-en.html
URL: http://mjiri.iums.ac.ir/article-1-7983-en.html
Hormozgan University of Medical Sciences, Bandar Abbas, Iran , dr.amirhosseinzarepur@gmail.com
Abstract: (226 Views)
Background: Heart failure (HF) is one of the most common and complex heart diseases that has a heavy burden on the health care system. Considering the role of supplements in improving heart diseases and increasing the quality of life of patients, in this study we aimed to investigate the effect of coenzyme Q10 on echocardiographic parameters in children with heart failure due to dilated cardiomyopathy.
Methods: In this pilot single-arm clinical trial, fifteen children with heart failure were included after obtaining written consent and medical history. They first underwent echocardiography and then were treated with oral coenzyme Q10, 10 mg/kg daily for 2 months. Then they underwent echocardiography again and the information was collected. Data were entered into SPSS ver. 20 software and depending on the data distribution, appropriate paired statistical tests were applied.
Results: Out of 15 patients participating in the study, 7 (46.7%) were female and 8 (53.3%) were male. The mean of EF before and after drug administration was 38.87 ± 15.81 and 43.40 ± 15.91, respectively. Also, the mean FS of patients before and after receiving the drug was 23.73 ± 7.81 and 25.73 ± 6.46, respectively (P < 0.001).
Conclusion: In this study, echocardiographic parameters of patients with HF due to dilated cardiomyopathy significantly improved after receiving coenzyme Q10, which indicates the possible positive effect of coenzyme Q10 on heart function and can probably be used in the treatment program of patients. Due to the pilot design of this study, more studies are needed in this field.
Methods: In this pilot single-arm clinical trial, fifteen children with heart failure were included after obtaining written consent and medical history. They first underwent echocardiography and then were treated with oral coenzyme Q10, 10 mg/kg daily for 2 months. Then they underwent echocardiography again and the information was collected. Data were entered into SPSS ver. 20 software and depending on the data distribution, appropriate paired statistical tests were applied.
Results: Out of 15 patients participating in the study, 7 (46.7%) were female and 8 (53.3%) were male. The mean of EF before and after drug administration was 38.87 ± 15.81 and 43.40 ± 15.91, respectively. Also, the mean FS of patients before and after receiving the drug was 23.73 ± 7.81 and 25.73 ± 6.46, respectively (P < 0.001).
Conclusion: In this study, echocardiographic parameters of patients with HF due to dilated cardiomyopathy significantly improved after receiving coenzyme Q10, which indicates the possible positive effect of coenzyme Q10 on heart function and can probably be used in the treatment program of patients. Due to the pilot design of this study, more studies are needed in this field.
: Original Research |
Subject:
Cardiology
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