Volume 15, Issue 1 (5-2001)                   Med J Islam Repub Iran 2001 | Back to browse issues page

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FOROOTAN H, NIKBIN B, ANANI SARAB G. ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN. Med J Islam Repub Iran 2001; 15 (1) :7-9
URL: http://mjiri.iums.ac.ir/article-1-817-en.html
ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
H FOROOTAN , B NIKBIN , GH ANANI SARAB
From the Departments of Internal Medicine and Immunogenetics, School of Medicine, Tehran University of Medical Sciences, Tehran
Abstract:   (4382 Views)
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared with dizygotic twin concordance, many implicate genetic factors in the development and regulation of the immune responses, such as the HLA class II genes, as candidates for conferring the genetic susceptibility. We studied the distribution of HLADR and DQ antigens and duration of sickness in 42 Iranian patients suffering from DC using the standard microlymphocytotoxicity technique. The phenotypic frequencies ofHLA-DR2 were present in 24 of 84 controls and 18 of 42 patients (p= 0.24, corrected p, not significant). The present study reveals no association between HLA class II antigens and UC, suggesting that the HLA-DR2 is not a predominant susceptibility gene for UC in the population studied.
Keywords: Ulcerative colitis; HLA phenotyping
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Type of Study: Original Research | Subject: Internal Medicine
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