Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Sat, Nov 23, 2024
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Volume 15, Issue 1 (5-2001)
Med J Islam Repub Iran 2001 |
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TAGHIZADEH-JAHROMI G, REZAYAT M, ZARRINDAST M. NMDA RECEPTOR ANTAGONISTS ATTENUATE TOLERANCE INDUCED BY MORPHINE AND NERVE LIGATION IN MICE. Med J Islam Repub Iran 2001; 15 (1) :41-47
URL: http://mjiri.iums.ac.ir/article-1-824-en.html
URL: http://mjiri.iums.ac.ir/article-1-824-en.html
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Abstract: (3847 Views)
The effect of NMDA (N-methyl-D-aspartate) receptor antagonists on tolerance
to morphine antinociception was investigated in mice. Daily subcutaneous
administration of 50 mg/kg of morphine hydrochloride for three days induced
tolerance to different (3,6 and 9 mg/kg) test doses of morphine. The tolerance
obtained was decreased by pretreatment of animals with single or repeated doses
of competitive NMDA receptor antagonists D-( -)-2-amino-5-phosphonovaleric
acid (DAP5 0.1-0.3 mg/kg) and D-(-)-2-amino-7-phosphonoheptanoic acid
(DAP7 0.1-0.3 mg/kg).
Tolerance to morphine response was also obtained 7, 14, 21 and 30 days
after unilateral sciatic nerve ligation. Single or repeated doses (0.2 mg/kg) of
DAP5 or DAP7 increased the antinociceptive response induced by morphine (9
mg/kg) in the nerve ligated animals. We report that these agents attenuate the
development of morphine tolerance, and increase the antinociceptive effect of
morphine on sciatic neuropathic pain in mice.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Pharmacology
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