Volume 14, Issue 4 (2-2001)                   Med J Islam Repub Iran 2001 | Back to browse issues page

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EBTEKAR M, KHANSARI N, SARRAFNEJAD A. DIFFERENTIAL EXPRESSION OF SURFACE MARKERS CD45RB AND CD44 ON MURINE CD8+ CELLS. Med J Islam Repub Iran 2001; 14 (4) :359-362
URL: http://mjiri.iums.ac.ir/article-1-839-en.html
DIFFERENTIAL EXPRESSION OF SURFACE MARKERS CD45RB AND CD44 ON MURINE CD8+ CELLS
M EBTEKAR , N KHANSARI , A SARRAFNEJAD
From the Department of Immunology, Tarbiat Modarres University, Tehran
Abstract:   (4041 Views)
Considering the emerging importance of phenotypic markers as indicators of cell function and differentiation, we studied patterns ofCD44 and CD45RB expression in CD8+ murine T cells with prior exposure to antigen or staphylococcal enterotoxin B ( SEB ). Following in vivo priming with two purified protein derivatives (one from a virulent WHO strain and the other from an avirulent strain), T cell enrichment was performed on murine spleen cells and followed by in vitro restimulation with SEB. Flow-cytometry studies were done to monitor the expression ofCD44 or CD45RB. Results indicate that primed or memory CD8+ cells do not display any significant change in the expression ofCD45RB. The expression ofCD44 exhibited significant variations among unprimed and primed mice and between different antigens. We were also able to see differential expression relevant to the virulence of the bacterial strain. This study suggests that by activation of those populations ofCD8+, CD44+ cells, resistance to virulent bacteria occurs.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Immunology
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