Volume 37, Issue 1 (2-2023)                   Med J Islam Repub Iran 2023 | Back to browse issues page

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Khodadadi M, Zare M, Ghasemi Z, Karimzadeh F, Golab F, Amini N, et al . High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices. Med J Islam Repub Iran 2023; 37 (1) :324-331
URL: http://mjiri.iums.ac.ir/article-1-8469-en.html
Cellular and Molecular Research Center, & Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran , joghataei.mt@iums.ac.ir
Abstract:   (462 Views)
Background: Neurostimulation is one of the new therapeutic approaches in patients with drug-resistant epilepsy, and despite its high efficiency, its mechanism of action is still unclear. On the one hand, electrical stimulation in the human brain is immoral; on the other hand, the creation of the epilepsy model in laboratory animals affects the entire brain network. As a result, one of the ways to achieve the neurostimulation mechanism is to use epileptiform activity models In vitro. In vitro models, by accessing the local network from the whole brain, we can understand the mechanisms of action of neurostimulation.
   Methods: A literature search using scientific databases including PubMed, Google Scholar, and Scopus, using "Neurostimulation" and "epileptiform activity" combined with "high-frequency stimulation", " low-frequency stimulation ", and "brain slices” as keywords were conducted, related concepts to the topic gathered and are used in this paper.
   Results: Electrical stimulation causes neuronal depolarization and the release of GABAA, which inhibits neuronal firing. Also, electrical stimulation inhibits the nervous tissue downstream of the stimulation site by preventing the passage of nervous activity from the upstream to the downstream of the axon.
   Conclusion: Neurostimulation techniques consisting of LFS and HFS have a potential role in treating epileptiform activity, with some studies having positive results. Further investigations with larger sample sizes and standardized outcome measures can be conducted to validate the results of previous studies.
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Type of Study: Review Article | Subject: Physiology

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