Volume 38, Issue 1 (1-2024)                   Med J Islam Repub Iran 2024 | Back to browse issues page

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Zamani A, Dehghan Manshadi M, Akouchekian M, Salahshouri far I. The Association of miRNA-146a Gene Variation and Multiple Sclerosis in The Iranian Population. Med J Islam Repub Iran 2024; 38 (1) :1-5
URL: http://mjiri.iums.ac.ir/article-1-8649-en.html
Department of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , akouchekian.m@iums.ac.ir
Abstract:   (544 Views)
Background: Multiple sclerosis (MS) is a complex human autoimmune-type inflammatory disease of the central nervous system (CNS). MicroRNA-146a (miR-146a) belongs to an endogenous and non-coding RNA family with 18-22 nucleotides long, which modulates the innate and adaptive immune response.
   Methods: Our study aimed to investigate a possible association between rs2910164 and rs2431697 polymorphisms of the miR-146a gene and multiple sclerosis in the Iranian population.
A total of 60 MS cases and 100 controls were recruited. Single nucleotide polymorphism (SNP) rs2431697 was genotyped by utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and SNP rs2910164 was genotyped by using Tetra-primer ARMS-PCR. Statistical Analysis conducted by the chi-squared test utilizing SPSS version 21.0 Software. The HardyWeinberg equilibrium assumption was evaluated.
   Results: The results of the present study suggest the miR-146a gene rs2431697 polymorphism is not associated with multiple sclerosis. However, there is a significant relationship between polymorphism rs2910164 of the miR-146a gene and multiple sclerosis in the population studied (P = 0.012).
   Conclusion: Our data provide evidence that the miR-146a gene may be involved in creating the susceptibility to MS in the Iranian population.

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Type of Study: Original Research | Subject: Medical Genetics

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