Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Wed, Dec 4, 2024
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Volume 14, Issue 3 (11-2000)
Med J Islam Repub Iran 2000 |
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A. ALAVIAN GHAVANINI A. ACUTE EXTRAPYRAMIDAL SYMPTOMS FOLLOWING ABRUPT DISCONTINUATION OF PROPRANOLOL. Med J Islam Repub Iran 2000; 14 (3) :305-306
URL: http://mjiri.iums.ac.ir/article-1-871-en.html
URL: http://mjiri.iums.ac.ir/article-1-871-en.html
From the Center for Research Consultation, School of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran. , alavianm@sums.ac.ir
Abstract: (4253 Views)
A case of acute extrapyramidal manifestations consisting of dystonia and
akathisia following abrupt discontinuation of propranolol is reported. She responded
well to oral propranolol and intramuscular diazepam. Extrapyramidal
symptoms have commonly been associated with acute or chronic administration
of neuroleptic drugs. There have been reports of a substantial number of cases
with similar clinical characteristics associated with tricyclic antidepressants,
monoamine oxidase inhibitors, and selective serotonin reuptake inhibitors. Although
it is known that beta-adrenoceptor antagonists are effective in the treatment
of extrapyramidal symptoms, especially akathisia, there has been no previous
report of such symptoms induced by abrupt withdrawal of these drugs. Although
she had been on low dose amitriptyline and had discontinued this medication
long before, prolonged use of amitriptyline may have had a predisposing role
in the development of these symptoms.
Type of Study: case report |
Subject:
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