NOYAN ASHRAF M H, BEHZADI G, JAMEIE B. RAPID EYE MOVEMENT SLEEP DEPRIVATION INDUCES ACETYLCHOLINESTERASE A CTIVITY IN THE PREOPTIC AREA OF THE RAT BRAIN. Med J Islam Repub Iran 2000; 14 (1) :47-51
URL:
http://mjiri.iums.ac.ir/article-1-900-en.html
From the Department of Anatomy. Faculty of Medicine. Cuilan University of Medical Sciences. Rasht Qazvin Road. Rasht. Cuilan. I.R. Iran. , noyan@cd.gu.ac.ir
Abstract: (3924 Views)
Acetylcholinesterase (AchE) is a large glycoprotein that, aside from its known
cholinolytic activity, co-exists with other transmitter systems and possesses other
functions. In the present study, the effects of short-term rapid-eye-movement sleep
deprivation (REM-SD) on AchE activity in the anterior hypothalamic area have
been investigated.
Using the flower-pot method, adult male albino rats were deprived of REM
sleep for a period of72, 96, and 120 h and perfused brains were then sectioned with
a vibratome and stained histochemically for AchE.
In comparison to control animals, marked positive AchE activity was
observed in neurons located in the preoptic area in the 120SD group only.
Results of this study have shown that AchE could be involved in some
unknown functions related to REM sleep physiology