From the Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, IR.Iran.
Abstract: (4333 Views)
The antinociceptive effect of Elaeagnus angustifolia fruits was studied in mice.
The antinociceptive effect of ethanolic and boiling water extracts was studied
using two thermal stimuli, the hot-plate and tail-flick tests. The intraperitoneal and
oral administration of the ethanolic extract of seed 0.75-7.00 g/kg), but not
pericarp and medulla had significant antinociceptive activity in the hot-plate test.
Naloxone pretreatment did not inhibit the antinociceptive activity of the extract.
The aqueous extract of different parts of the fruit (seed, medulla and pericarp) had
antinociceptive activity in this test. The ethanolic extract of the seed had no
antinociceptive effect in the tail-flick test and its effect was not abolished by
naloxone. A 70% failure rate in the traction test (a muscle relaxation test) was
induced by ethanolic extract of the seed (3.5 g/kg), compared with the 75% induced
by the reference drug diazepam (2.5 mg/kg). It is concluded that the antinociceptive
effect of E. angustifolia may be mediated by a supraspinal effect and muscle
relaxation activity.