Volume 14, Issue 1 (5-2000)                   Med J Islam Repub Iran 2000 | Back to browse issues page

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SHAHRIARI H, HOSSEINI RAD A. PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIM AL MODEL. Med J Islam Repub Iran 2000; 14 (1) :83-86
URL: http://mjiri.iums.ac.ir/article-1-907-en.html
PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIM AL MODEL
HA SHAHRIARI , A HOSSEINI RAD
From Zahedan University of Medical Sciences, Dr. Shariati Ave, Zahedan, 98134, I.R . Iran.
Abstract:   (3629 Views)
In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced retinopathy, ERG waves were compared before and after methanol intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups received 4 g/kg of methanol intraperitoneally. In addition, the second, third and fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin B12 and folic acid, respectively. Baseline ERGs were recorded for all rabbits prior to intoxication and then second ERGs were taken 48-72 hours following methanol toxicity. Compared to baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in the oscillatory potential were noticed. Among all groups, the first group had the most and the fourth group had the least decrease in b-wave amplitude as well as oscillatory potential. It is therefore believed that vitamin B12 has a synergistic effect with folic acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are needed to evaluate these effects in humans.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Drug
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