Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Mon, Dec 30, 2024
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Volume 38, Issue 1 (1-2024)
Med J Islam Repub Iran 2024 |
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Moradi Moghaddam O, Gorjizadeh M, Sedighi M, Amanollahi A, Khatibi A, Ghodrati M et al . Determining Predictive Power of Base Excess in Comparison with SOFA Score for Predicting Mortality in ICU Patients. Med J Islam Repub Iran 2024; 38 (1) :508-511
URL: http://mjiri.iums.ac.ir/article-1-9170-en.html
URL: http://mjiri.iums.ac.ir/article-1-9170-en.html
Omid Moradi Moghaddam 
, Mohammajavad Gorjizadeh , Mohsen Sedighi , Alireza Amanollahi , Ali Khatibi , Mohammadreza Ghodrati , Mohammad Niakan Lahiji
, Mohammajavad Gorjizadeh , Mohsen Sedighi , Alireza Amanollahi , Ali Khatibi , Mohammadreza Ghodrati , Mohammad Niakan Lahiji
Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran & Department of Anesthesiology and Critical Care, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , niyakanlahiji.m@iums.ac.ir
Abstract: (409 Views)
Background: Acid-base disturbances are frequently found in intensive care unit (ICU) patients. Base excess (BE) is commonly used to quantify the degree of metabolic impairment. We aimed to compare the predictive value of BE and Sequential Organ Failure Assessment (SOFA) score for mortality in ICU patients.
Methods: This prospective and observational investigation was performed on 87 ICU patients who underwent mechanical ventilation. SOFA score and acid-base variables at 6 hours of ICU admission were analyzed and compared between survivors and non-survivors. Receiver-operating characteristic (ROC) curve was applied to analyze the predictive value of BE and SOFA for mortality.
Results: Mean age of patients was 63.91±5.03 years, and 60 (69%) were male. The non-survived patients had significantly higher SOFA (P = 0.001) and APACHE II scores (P = 0.001). The non-survived patients had a lower bicarbonate (P = 0.002), PO2 (P = 0.001), pH (P = 0.0021), and a higher PCO2 (P = 0.001) compared with survivors, and most patients who died (80%) had a low BE value (< -2) (P = 0.002). The estimated AUC of SOFA and BE was 0.83 (95% CI, 0.73 - 0.92) and 0.71 (95% CI, 0.57 – 0.85), respectively.
Conclusion: BE is, to some extent capable of predicting mortality in ICU patients. However, the SOFA score is a more accurate and reliable parameter in comparison to BE for prediction.
Methods: This prospective and observational investigation was performed on 87 ICU patients who underwent mechanical ventilation. SOFA score and acid-base variables at 6 hours of ICU admission were analyzed and compared between survivors and non-survivors. Receiver-operating characteristic (ROC) curve was applied to analyze the predictive value of BE and SOFA for mortality.
Results: Mean age of patients was 63.91±5.03 years, and 60 (69%) were male. The non-survived patients had significantly higher SOFA (P = 0.001) and APACHE II scores (P = 0.001). The non-survived patients had a lower bicarbonate (P = 0.002), PO2 (P = 0.001), pH (P = 0.0021), and a higher PCO2 (P = 0.001) compared with survivors, and most patients who died (80%) had a low BE value (< -2) (P = 0.002). The estimated AUC of SOFA and BE was 0.83 (95% CI, 0.73 - 0.92) and 0.71 (95% CI, 0.57 – 0.85), respectively.
Conclusion: BE is, to some extent capable of predicting mortality in ICU patients. However, the SOFA score is a more accurate and reliable parameter in comparison to BE for prediction.
Type of Study: Original Research |
Subject:
Internal Medicine
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