Volume 13, Issue 4 (2-2000)                   Med J Islam Repub Iran 2000 | Back to browse issues page

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VODJGANI M, ANSARI K, HAJATI J. ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS. Med J Islam Repub Iran 2000; 13 (4) :265-267
URL: http://mjiri.iums.ac.ir/article-1-918-en.html
ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS
M VODJGANI , KE ANSARI , J HAJATI
From the Department of Immunology. Faculty of Medicine. Tehran University of Medical Sciences. Tehran. I.R. Iran.
Abstract:   (4222 Views)
Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients with autoimmune and vascular diseases such as Wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence (IIF) technique was employed to detect these autoantibodies. By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA) and a perinuclear form (p-ANCA). These antibodies were also observed in rheumatoid arthritis (RA) but their prevalence and clinical significance have not been determined. In this study the presence of ANCA in 52 RA patients (10 males and 42 females) and its relationship with disease activity was evaluated. 26.9% of patients were ANCA-positive, 36% of whom had c-ANCA and 64% a p-ANCA pattern. The results also showed that there is no significant correlation between ANCA titer and disease activity (p
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Type of Study: Original Research | Subject: Immunology
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