Volume 13, Issue 3 (11-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page

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EINOLLAHI B, KHATAMI M, LESANPEZESHKI M, BAKHTIARI P, AMIRJALALI V, FIROUZAN A. RENAL ALLOGRAFT ACCUMULATION OF TECHNETIUM-99M SULFUR COLLOID AS A PREDICTOR OF GRAFT REJECTION. Med J Islam Repub Iran 1999; 13 (3) :185-189
URL: http://mjiri.iums.ac.ir/article-1-935-en.html
RENAL ALLOGRAFT ACCUMULATION OF TECHNETIUM-99M SULFUR COLLOID AS A PREDICTOR OF GRAFT REJECTION
BEHZAD EINOLLAHI , MOHAMMADREZA KHATAMI , MAHBOOB LESANPEZESHKI , PEJMAN BAKHTIARI , VIOLET AMIRJALALI , AHMAD FIROUZAN
From the Department of Nephrology, Baghiyatollah Hospital, Baghiyatollah University of Medical Sciences
Abstract:   (4721 Views)
A perplexing issue in diagnosing the cause of renal allograft dysfunction is differentiation between rejection----the most common cause--and many other possibilities that have detrimental effects on graft function. This study was designed to determine whether technetium - 99m sulfur colloid (TSC) accumulation could predict graft rejection. We prospectively studied 54 episodes of allograft dysfunction in 53 kidney transplant recipients who had undergone TSC scintiscanning and graft biopsy, within one week of evidence of allograft dysfunction. Visual analysis of TSC uptake was done by comparing allograft uptake with that of the fifth lumbar vertebra (L5) marrow. A 3+ result meant that allograft uptake was greater than L5 marrow uptake 2+, allograft uptake was the same as L5 marrow uptake 1+, less than and 0, no allograft uptake. Transplant accumulation of 􀁀2+ was considered consistent with rejection (p=0.01). Allotransplant biopsies were interpreted based on the Banff Working Classification and rejection was noted in 45 of 54 renal biopsies. 42 of 45 biopsy -proven rejection episodes had ≥2+ graft uptake. This nuclear medicine technique has a sensitivity of 93.3%, specificity of 44.4%, a positive predictive value of 89.3%, a negative value of 57.1 % and an efficiency of 83.3% in the diagnosis of renal allograft rejection.
Keywords: Kidney transplantation, Allograft dysfunction, Rejection, Technetium-99m sulfur colloid.
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Type of Study: Original Research | Subject: Nephrology
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