Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Mon, Jan 13, 2025
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Volume 38, Issue 1 (1-2024)
Med J Islam Repub Iran 2024 |
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Hashemi-Madani N, Azadi M, Khajavi A, Emami Z, Khamseh M E. Peripheral Arterial Disease is Associated with Sensorimotor Peripheral Neuropathy in People with Type 2 Diabetes. Med J Islam Repub Iran 2024; 38 (1) :1160-1165
URL: http://mjiri.iums.ac.ir/article-1-9368-en.html
URL: http://mjiri.iums.ac.ir/article-1-9368-en.html
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran , khamseh.m@iums.ac.ir
Abstract: (135 Views)
Background: Micro- and macro-vascular complications of diabetes seem to be interconnected. This study aimed to evaluate the association between peripheral arterial diseases (PAD) and diabetic sensorimotor peripheral neuropathy (DSPN).
Methods: This cross-sectional study was conducted among 748 people with type 2 diabetes (T2DM) referred to a tertiary care center between 2017 and 2022. PAD was defined as Ankle-brachial index (ABI) ≤ 0.9. Loss of protective sensation (LOPS) was applied for the detection of DSPN. Logistic regression analysis was used to determine the association between PAD and DSPN.
Results: The mean age of the participants was 59.6 (±8.8) years, and the median duration of diabetes was 10 (5-16) years. LOPS was detected in 491 individuals (65.6%). ABI ≤ 0.9 was associated with a significantly higher risk of LOPS (OR: 3.65, 95% Confidence Interval (CI): 1.97- 6.74). In addition, every 0.1 decrease in ABI increased the risk of LOPS by 21% (95%CI: 10- 34%). Toe brachial index (TBI) ≤0.7 was also associated with a significantly higher risk of LOPS (OR: 1.77, 95%CI: 1.28- 2.46). Each 0.1 decrease in TBI increased the risk of LOPS by 19% (95%CI: 10- 28%).
Conclusion: PAD is strongly associated with DSPN. Assessment of DSPN could be considered in the presence of PAD.
Methods: This cross-sectional study was conducted among 748 people with type 2 diabetes (T2DM) referred to a tertiary care center between 2017 and 2022. PAD was defined as Ankle-brachial index (ABI) ≤ 0.9. Loss of protective sensation (LOPS) was applied for the detection of DSPN. Logistic regression analysis was used to determine the association between PAD and DSPN.
Results: The mean age of the participants was 59.6 (±8.8) years, and the median duration of diabetes was 10 (5-16) years. LOPS was detected in 491 individuals (65.6%). ABI ≤ 0.9 was associated with a significantly higher risk of LOPS (OR: 3.65, 95% Confidence Interval (CI): 1.97- 6.74). In addition, every 0.1 decrease in ABI increased the risk of LOPS by 21% (95%CI: 10- 34%). Toe brachial index (TBI) ≤0.7 was also associated with a significantly higher risk of LOPS (OR: 1.77, 95%CI: 1.28- 2.46). Each 0.1 decrease in TBI increased the risk of LOPS by 19% (95%CI: 10- 28%).
Conclusion: PAD is strongly associated with DSPN. Assessment of DSPN could be considered in the presence of PAD.
Keywords: Peripheral artery disease, Diabetes, Sensorimotor peripheral neuropathy, Ankle-brachial index, Loss of protective sensation
Type of Study: Original Research |
Subject:
Endocrinology
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