Volume 13, Issue 2 (8-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page

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SARI Z, ZARRINDAST M, ROUSHANZAMIR F. MORPHINE AND APOMORPHINE INHIBIT GASTROINTESTINAL TRANSIT (GIT) THROUGH TWO DIFFERENT MECHANISMS. Med J Islam Repub Iran 1999; 13 (2) :133-138
URL: http://mjiri.iums.ac.ir/article-1-957-en.html
MORPHINE AND APOMORPHINE INHIBIT GASTROINTESTINAL TRANSIT (GIT) THROUGH TWO DIFFERENT MECHANISMS
ZAHRA SARI , MR ZARRINDAST , F ROUSHANZAMIR
From the Department of Physiology, Arak University of Medical Sciences, Arak
Abstract:   (4017 Views)
Morphine was used as a remedy for the control of diarrhea centuries before it's sedative-analgesic effect was discovered. Although several mechanisms have been proposed for the morphine-induced inhibition of gastrointestinal transit (OIT), the exact mechanism has not yet been identified. On this basis the possible involvement of the dopaminergic system in morphine-induced inhibition of transit was investigated. This study showed that morphine decreased gastrointestinal transit (OIT) of charcoal dust in mice.in a dose-dependent manner. The response was inhibited by the opiate antagonist naloxone. Pretreatment of animals with the D-2 antagonist sulpiride or the peripheral dopamine antagonist domperidone did not alter the morphine-induced inhibition of OIT. The D-l/D-2 agonist apomorphine also decreased OIT in mice. The response was inhibited by SCH 23390 or sulpiride pretreatment (p<0.01), but not by domperidone or naloxone. It is concluded that morphine and apomorphine inhibit OIT through opiate and dopaminergic mechanisms, respectively.
Keywords: Morphine, Dopamine, Gastrointestinal transit.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Physiology
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