Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Sat, Nov 30, 2024
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Volume 13, Issue 2 (8-1999)
Med J Islam Repub Iran 1999 |
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SADRAEI H, HAJHASHEMI V. INHIBITORY EFFECT OF KETOTIFEN ON CONTRACTIONS OF RAT ISOLATED BLADDER. Med J Islam Repub Iran 1999; 13 (2) :151-155
URL: http://mjiri.iums.ac.ir/article-1-960-en.html
URL: http://mjiri.iums.ac.ir/article-1-960-en.html
From the Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences ,Isfahan, I.R. Iran.
Abstract: (3931 Views)
Ketotifen is a benzocycloheptathiophene with a range of pharmacological
activities. The present study was carried out to evaluate the action of ketotifen on
isolated rat bladder contractions induced by KCI and acetylcholine, compared with
the effects of other drugs. Ketotifen (5 µM) reduced the response to acetylcholine
on rat isolated bladder without altering the maximum response and shifted the
acetylcholine concentration-response curve to the right 16 - fold. Ketotifen also
reduced the KCl response, while atropine only inhibited the response to acetylcholine.
Diazoxide inhibited bladder - induced contraction only at high concentration (500
µM). This study shows that ketotifen is a relaxant of isolated rat bladder. As the
inhibition of contractile overactivity of the bladder is the basis of treatment of
bladder instability, provided that a similar effect will be seen in vivo, then ketotifen
may have clinical benefits for treatment of this condition.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Pharmacology
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