Volume 12, Issue 4 (2-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page

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ZARE MEHRJARDI A, MASSOUMIAN M. DISCRIMINATION OF HEPATOCELLULAR CARCINOMA FROM CIRRHOTIC NODULES BY AgNOR STAIN. Med J Islam Repub Iran 1999; 12 (4) :329-331
URL: http://mjiri.iums.ac.ir/article-1-983-en.html
DISCRIMINATION OF HEPATOCELLULAR CARCINOMA FROM CIRRHOTIC NODULES BY AgNOR STAIN
ALI ZARE MEHRJARDI , MEHDI MASSOUMIAN
From the Department of Pathology, Kerman University of Medical Sciences, Kerman, I.R. Iran
Abstract:   (3628 Views)
Discrimination of regenerative cirrhotic nodules of the liver (CN) from hepatocellular carcinoma (HCC) is sometimes difficult. We examined the utility of AgNOR staining in this context. Fifteen cases of HCC and 25 cases of CN were stained by AgNOR method and the mean AgNOR number for one hundred nuclei in each case was determined. There was a significant difference between the mean AgNOR counts in CN (6.63±4.00) and HCC (11.36±2.88) (p<0.0005). Discriminant analysis showed that all HCC cases and over 90% of CN could be correctly distinguished by this method. It seems that AgNOR staining is an accurate and readily available tool for differentiating CN from HCC.
Keywords: Cirrhosis, Cirrhotic nodule, Hepatocellular carcinoma, AgNOR.
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Type of Study: Original Research | Subject: Pathology
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