Medical Journal of The Islamic Republic of Iran (MJIRI)
Iran University of Medical Sciences
Tue, Feb 17, 2026
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Volume 40, Issue 1 (1-2026)
Med J Islam Repub Iran 2026 |
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Toleutayeva D, Shalgumbayeva G, Tukinova A, Dyussenova L, Toleutayev T. Incidence, Mortality and Five-Year Survival of Colorectal Cancer in the Republic of Kazakhstan (2013–2023). Med J Islam Repub Iran 2026; 40 (1) :17-24
URL: http://mjiri.iums.ac.ir/article-1-9838-en.html
URL: http://mjiri.iums.ac.ir/article-1-9838-en.html
Department of Epidemiology and Biostatistics, NJSC Semey Medical University, Semey, Kazakhstan , tukinova.asel@bk.ru
Abstract: (47 Views)
Background: Colorectal cancer remains a significant public health concern globally and in Kazakhstan, with rising incidence rates partly attributed to improved screening and lifestyle changes. This study aimed to assess epidemiological trends in colorectal cancer in Kazakhstan from 2013 to 2023, focusing on incidence, mortality, and five-year survival rates.
Methods: This population-based registry analysis utilized national cancer registry data on colorectal cancer (CRC) morbidity and mortality. All registered cases from 2013 to 2023 were included. Five-year survival was estimated using aggregated registry data (observed survival). Temporal trends were evaluated using simple linear regression.
Results: Between 2013 and 2023, colorectal cancer incidence in Kazakhstan slightly increased (from 8.9 to 9.8 per 100,000), while mortality significantly decreased by 32.7% (from 4.9 to 3.3; B = –6.64, reflecting an overall downward trend over the study period; P < 0.001), particularly in East Kazakhstan. Rectal cancer incidence increased in South Kazakhstan (B = 5.46; P = 0.007) and Astana (B = 1.59; P = 0.014), but declined in the Almaty region (B = –1.88; P = 0.008). Mortality decreased notably in the Almaty region, Almaty city, and North Kazakhstan. Five-year observed survival rates for CRC improved from 44.1% to 52.0%, and for rectal cancer from 42.0% to 47.0%.
Conclusion: Despite the decline in colorectal cancer mortality in Kazakhstan from 2013 to 2023, the persistently high rate of late-stage diagnoses underscores the urgent need to strengthen early detection efforts and implement region-specific interventions.
Methods: This population-based registry analysis utilized national cancer registry data on colorectal cancer (CRC) morbidity and mortality. All registered cases from 2013 to 2023 were included. Five-year survival was estimated using aggregated registry data (observed survival). Temporal trends were evaluated using simple linear regression.
Results: Between 2013 and 2023, colorectal cancer incidence in Kazakhstan slightly increased (from 8.9 to 9.8 per 100,000), while mortality significantly decreased by 32.7% (from 4.9 to 3.3; B = –6.64, reflecting an overall downward trend over the study period; P < 0.001), particularly in East Kazakhstan. Rectal cancer incidence increased in South Kazakhstan (B = 5.46; P = 0.007) and Astana (B = 1.59; P = 0.014), but declined in the Almaty region (B = –1.88; P = 0.008). Mortality decreased notably in the Almaty region, Almaty city, and North Kazakhstan. Five-year observed survival rates for CRC improved from 44.1% to 52.0%, and for rectal cancer from 42.0% to 47.0%.
Conclusion: Despite the decline in colorectal cancer mortality in Kazakhstan from 2013 to 2023, the persistently high rate of late-stage diagnoses underscores the urgent need to strengthen early detection efforts and implement region-specific interventions.
Type of Study: Original Research |
Subject:
Biostatistics and Epidemiology
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