Volume 12, Issue 4 (2-1999)                   Med J Islam Repub Iran 1999 | Back to browse issues page

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SAYYAH M, POURGHOLAMI M. LACK OF ANTICONVULSANT ACTIVITY OF INTRACEREBROVENTRICULAR PROGESTERONE AND ALLOPREGNANOLONE IN MALE AMYGDALA-KINDLED RATS. Med J Islam Repub Iran 1999; 12 (4) :337-380
URL: http://mjiri.iums.ac.ir/article-1-991-en.html
LACK OF ANTICONVULSANT ACTIVITY OF INTRACEREBROVENTRICULAR PROGESTERONE AND ALLOPREGNANOLONE IN MALE AMYGDALA-KINDLED RATS
M SAYYAH , MH POURGHOLAMI
From the Department of Pharmacology, Faculty of Medicine, Shaheed Beheshti University of Medical
Abstract:   (3417 Views)
The effect of intracerebroventricular administration of progesterone and its metabolite allopregnanolone(3a-hydroxy-5a-pregnane-20-one)on the amygdala kindling model of seizures was studied in male rats. Neither progesterone (10, 50, 200 􀁏g/rat) nor allopregnanolone (12.5, 50, 100 µg/rat) had any effect on seizure parameters at 5, 15 and 30 min. after administration. Although previous studies imply the anticonvulsanteffect of progesterone and its metabolite allopregnanolone against seizures induced by GABAA receptor antagonists, the present data do not support the anticonvulsant activity of these two steroids in amygdala-kindled seizures.
Keywords: Seizure, Progesterone, Allopregnanolone, Amygdala-kindled rats.
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Type of Study: Original Research: Basic Science in Medicine | Subject: Pharmacology
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