Volume 12, Issue 3 (11-1998)                   Med J Islam Repub Iran 1998 | Back to browse issues page

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NASSERI P, GHAVAMZADEH A, JAHANI M, KHODABANDEH A, BAYBORDI I, MOHYEDDIN M et al . ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA. Med J Islam Repub Iran 1998; 12 (3) :217-220
URL: http://mjiri.iums.ac.ir/article-1-997-en.html
ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA
P NASSERI , A GHAVAMZADEH , M JAHANI , A KHODABANDEH , I BAYBORDI , M MOHYEDDIN , G GHAHREMANI
From the BMT Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract:   (4391 Views)
Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respectively. Eleven patients are alive (61 %) and seven (39%) died. Twelve patients developed acute GVHD. We found an inverse relationship between the incidence of acute GVHD and the number of units of transfused packed cells and platelets before BMT (p 1000, PLT> 100000) after BMT was inversely related to the total number of cells transplanted (p<0.05).
Keywords: Aplastic anemia, Bone marrow transplantation
Full-Text [PDF 437 kb]   (1542 Downloads)    
Type of Study: Original Research | Subject: Oncology
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