RAFIEI S, MOSAFA N. ANTI-ENDOTHELIAL CELL ANTIBODIES AND CIRCULATING IMMUNE COMPLEXES, A POSSIBLE PROGNOSTIC TOOL IN IDDM ANGIOPATHY. Med J Islam Repub Iran 1989; 3 (1 and 2) :69-74
URL:
http://mjiri.iums.ac.ir/article-1-1603-en.html
From the Department of Immunology and Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract: (4112 Views)
52 patients suffering from ID D M (insulin-dependent diabetes mellitus)
were studied for anti-endothelial cell antibodies (AEA) and circulating
immune complexes (CIC).
20 had a high CI C level, and eight demonstrated AEA, of whom five had
retinopathy and three did not show any obvious vascular complication. It has
been shown that C3, C4 and CH50 levels were also decreased. AEA were
evaluated by indirect immunoflourescent technique, using rat pancreas
tissue as the antigen. To estimate the CIC level, PEG precipitating method
was used.
It was suggested that bydemonstratingAEJ', we will be able o evaluate
the prognosis ofIDDM, especially the long standing phase, with no vascular
complication.