Volume 19, Issue 2 (8-2005)                   Med J Islam Repub Iran 2005 | Back to browse issues page

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PARSANEZHAD M E, PAKNIAT M, ALBORZI S, SCHMIDT E H. A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED STUDY TO ASSESS THE EFFICACY OF KETOCONAZOLE FOR REDUCING THE RISK OF OVARIAN HYPERSTIMULATION SYNDROME. Med J Islam Repub Iran 2005; 19 (2) :153-158
URL: http://mjiri.iums.ac.ir/article-1-509-en.html
A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED STUDY TO ASSESS THE EFFICACY OF KETOCONAZOLE FOR REDUCING THE RISK OF OVARIAN HYPERSTIMULATION SYNDROME
MOHAMMAD EBRAHIM PARSANEZHAD , MAHNAZ PAKNIAT , SAEED ALBORZI , ERNST HEINRICH SCHMIDT
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , parsame@sums.ac. ir
Abstract:   (5041 Views)
 

ABSTRACT

 

Background: In order to evaluate the role ofketoconazole in the prevention of ovarian hyperstimulation syndrome (OHSS) in women with polycystic ovary syndrome (PCOS) undergoing ovarian stimulation with gonadotropins, a prospective, randomized, double-blind, placebo controlled study was done on one-hundred and nine PCOS women that had been refeiTed to be treated by gonadotropins.

 

Methods: Alll09 women were assigned for random allocation. Group A (50 patients) received two ampoules ofhMG beginning on day 2 or 3 of the cycle and ketoconazole (50 mg/every 48 hours) starting on the first day ofhMG treatment. Group B (51 patients) received the same protocol ofhMG combined with one tablet of placebo every 48 hours. Main outcome measures were follicular development, E2levels, and pregnancy rate.

 

Results: The total number ofhMG ampoules and duration oftreatment to attain ovarian stimulation was higher in group A (p

 

Conclusion: Ketoconazole has no effect in prevention of OHSS in PCOS patients undergoing ovarian stimulation. It may however reduce the rate of folliculogenesis and steroidogenesis.

 
Keywords: Polycystic ovary syndrome. ovarian hyperstimulation syndrome, ketoconazole.
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Type of Study: Original Research | Subject: Gynecology & Obstetrics
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