MARDANI M, KESHTKAR JAHROMI M, HOLAKOI NAINI K, ZINALI M. THE EFFICACY OF ORAL RIBAVIRIN IN THE TREATMENT OF 81 PROVED CASES OF CRIMEAN-CONGO HEMORRHAGIC FEVER (CCHF) IN IRAN (1999-2001). Med J Islam Repub Iran 2003; 17 (3) :193-195
URL:
http://mjiri.iums.ac.ir/article-1-680-en.html
From the Dept. of Infectious Diseases and Tropical Medicine, Shaheed Beheshti University of Medical Sciences, and the Dept. of Epidemiology, Tehran University of Medical Sciences, Tehran, Iran. , mmardani@sbmu.ac.ir
Abstract: (5107 Views)
Crimean-Congo Hemorrhagic Fever is a fatal viral disease that occurs in
some parts of Africa, Asia, Eastern Europe and the Middle-East. Primarily it is a
zoonosis but can be seen sporadically in humans. Recently outbreaks have been
reported from Pakistan, Afghanistan, Saudi Arabia, United Arab Emirates and
Iran. In this retrospective study, we evaluated the efficacy of oral Ribavirin in the
treatment of CCHF cases, by comparing the outcome in two groups of treated and
non-treated confirmed CCHF cases. 81 confirmed CCHF cases (by serology or
viral culture) were evaluated for the incidence of outcome (death or recovery ) in
the form of an analytic case-control study. 61 out of 69 treated cases and 5 out of
12 non-treated cases survived. Oral Ribavirin with an efficacy of 91 % can be an
effective medical therapy for management of Crimean Congo Hemorrhagic Fever.