Medical Journal of The Islamic Republic of Iran (MJIRI)

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During a 6 year period from September 1992 to September 1998, 165 children with a final diagnosis of Henoch-Schonlein purpura (HSP) were managed and followed in our center. There were 87 (52%) boys and 78 (48%) girls, with age ranges of 1-16 years and mean age of 7.8 years. Forty-one percent of the patients had evidence of preceding upper respiratory tract infection (URI). The main clinical features were: skin eruption in 100%, OI symptoms in 79.5%,joint problems in 59.5% and renal involvement in 26.5% of cases. Thrombocytosis in 31 % and increased ESR in 55% of cases were the main significant laboratory findings. Abdominal sonography was done in 58 cases with GI symptoms, and was abnormal in 28 cases (48%): free peritoneal fluid in 26%, thickened bowel wall in 14%, ileus in 5% and intussusception in 3%. Sixty percent of the patients received prednisolone for OI problems or renal involvement. Nine percent of the cases had relapse and there was no death. It was concluded that: a) There is no significant sex difference in children with HSP in this area. b) The age of children with HSP in this area is the same as those in eastern countries, but relatively higher than that reported in western countries. c) Abdominal sonography can be a helpful means of diagnosis in patients with OI manifestations of HSP before skin eruption. d) The morbidity and mortality of HSP is very low if the disease is diagnosed in its early stages and managed properly.

Keywords: Henoch-Schonlein purpura, Children, Ultrasonography, Mortality and Morbidity.

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