OSTAD S, KEBRIAEE-ZADEH A, ZAREKAMALI R, ABDOLLAHI M, MARZBAN H, AKHGARI M. THE PROTECTIVE EFFECT OF INDOMETHACINE ON SULFUR MUSTARD-INDUCED OCULAR DAMAGE IN THE RABBIT EYE. Med J Islam Repub Iran 2001; 14 (4) :385-391
URL:
http://mjiri.iums.ac.ir/article-1-844-en.html
From the Department of Toxicology and Pharmacology, Faculty of Pharmacy Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran. , snostad@yahoo.com
Abstract: (4578 Views)
Sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. The
injury is a result of late inflammation, which is mediated by prostaglandins. Theoretically,
inhibition of prostaglandins by reagents such as indomethacine could
result in alleviation of clinical adverse effects. In this study, the protective effect
of topically applied indomethacine against sulfur mustard toxicity was assessed
on the rabbit eye. Ocular toxicity was studied by using light microscopy, electron
microscopy and visual inspection methods. Methods used in this assay showed
that 100 µL of indomethacine solution (0.5% W N) two hours before exposure
and throughout the experiment could markedly decrease the toxic effects of mustard.