Volume 14, Issue 4 (2-2001)                   Med J Islam Repub Iran 2001 | Back to browse issues page

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OSTAD S, KEBRIAEE-ZADEH A, ZAREKAMALI R, ABDOLLAHI M, MARZBAN H, AKHGARI M. THE PROTECTIVE EFFECT OF INDOMETHACINE ON SULFUR MUSTARD-INDUCED OCULAR DAMAGE IN THE RABBIT EYE. Med J Islam Repub Iran 2001; 14 (4) :385-391
URL: http://mjiri.iums.ac.ir/article-1-844-en.html
THE PROTECTIVE EFFECT OF INDOMETHACINE ON SULFUR MUSTARD-INDUCED OCULAR DAMAGE IN THE RABBIT EYE
SN OSTAD , A KEBRIAEE-ZADEH , R ZAREKAMALI , M ABDOLLAHI , H MARZBAN , M AKHGARI
From the Department of Toxicology and Pharmacology, Faculty of Pharmacy Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran. , snostad@yahoo.com
Abstract:   (4578 Views)
Sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. The injury is a result of late inflammation, which is mediated by prostaglandins. Theoretically, inhibition of prostaglandins by reagents such as indomethacine could result in alleviation of clinical adverse effects. In this study, the protective effect of topically applied indomethacine against sulfur mustard toxicity was assessed on the rabbit eye. Ocular toxicity was studied by using light microscopy, electron microscopy and visual inspection methods. Methods used in this assay showed that 100 µL of indomethacine solution (0.5% W N) two hours before exposure and throughout the experiment could markedly decrease the toxic effects of mustard.
Keywords: Mustard, Inflammation, Cornea, Indomethacine, Eye, Ocular
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Type of Study: Original Research: Basic Science in Medicine | Subject: Pharmacology
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